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Coronavirus disease-19 (COVID-19) is a critical health challenge in all countries and according to united nation report, one of the most common problems during COVID -19 is the bacterial resistance to antimicrobial drugs that face the health issues which is due to antibiotics misuses during the pandemic disease as a protective to expected secondary bacterial infections after a viral infection. Subsequently COVID-19 early phase courage or enhance this massive antibiotic use in several countries all over the world. The purpose of this review to cover the prevalence and reasons behind these antibiotics misuse and analyze most common antibiotics uses during early-phase COVID-19 pandemic.