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Citrullus colocynthis and Silbum Marian as therapeutic agent in metabolic syndrome Rrattus model

by Abdullah Talal Al-Nuaymia1, Muhammad Ahmed Ahmed Al Kataan2

  1. 1College of pharmacy,University of Mosul, Iraq, College of Medicine, Ninevah Univrsity, Iraq
  2. 2College of Medicine, Ninevah Univrsity, Iraq
Pharmacy and Applied Health Sciences 2023, 2(1), 23-28; https://doi.org/10.59480/phahs.v1i2.16
Received: January 9, 2023Published: June 30, 2023
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Abstract

Background: Plants represent a treasure chest with many unrevealed medical applications as hypoglycemic and antioxidant roles. A pathological condition characterized by hyperglycemia, insulin resistance, and dyslipidemia  known as metabolic syndrome. Objectives: This work focuses on examining the hypoglycemic effect of three plants on a metabolic syndrome( MS)-induced animal model and studying the role of the extracted phenolic compounds on different mitochondrial function genomic parameters. Methods: Citrullus colocynthis, Silbum Marian, and Rheum rhabarbarum phenolic compounds extracted and quantified using the Folin–Ciocalteu reagent, as described by Sánchez-Rangel et al. (2013).Forty albino rats were included in the work. They were divided into eight groups of five animals each as follows: negative control (normal), positive control (MS induced with fructose with no treatment), and MS treatment with Citrullus colocynthis, MS treatment with Silbum Marian, and MS treatment with Rheum rhabarbarum. Non-MS animals treated with Citrullus colocynthis Non-metabolic syndrome animals treated with Silbum Marian and non-MS animals treated with Rheum rhabarbarum. Serum glucose, Lipid profile, liver function tests, serum glucose, lactate, pyruvate, and molar lactate/pyruvate ratio. Genomic study was conducted by qPCR  Conclusion: metabolic syndrome significantly reduce mitochondrial genome copies number. The application of the ethanolic extract of Citrullus colocynthis and Silbum Marian       

phenolic compoundsglycemic profilemitochondrial copies numberaction potentiallactate: pyruvate ratio.

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