https://phahs.knu.edu.iq/index.php/phahs/issue/feed Pharmacy and Applied Health Sciences 2023-06-30T00:00:00+00:00 Dr. Nahla Abdalhamed Abdaljabar [email protected] Open Journal Systems <p>Pharmacy and Applied Health Sciencess (PHAHS) is an open access online peer-reviewed international Journal that encourages researchers to make beneficial contributions in Pharmacy and Health Sciences. Case reports, original research work (either as a Full Research Paper or as a Short Communication), and review articles are published in the Journal. The Journal's mission is to provide high-quality scientific publications in the field of pharmacy and health sciences. For a qualitative and rapid review process, the Journal employs the Editorial Tracking System. Review processing is handled by the Health Science Journal editorial board members or relevant experts from other universities and institutes. Acceptance of any citable manuscript requires the approval of at least two independent reviewers, followed by editor approval. Authors can use the Online Manuscript Submission to submit manuscripts and follow their progress.</p> https://phahs.knu.edu.iq/index.php/phahs/article/view/15 Development and Application of Structure Assisted Atom Based de Novo Molecular Design (SAAD) Approach using matlab 2022-11-19T07:33:41+00:00 Mohammed Al-Qattan [email protected] Mohd Nizam Mordi [email protected] <p>In the context of drug design and development, phytochemical and synthetic libraries are starting places for searching leads. However, knowing crystal structure of receptor may help scratching molecules that complements available interaction sites using <em>de novo</em> molecular design approaches. This research describes the implementation of genetic algorithm optimization technique for construction of molecular scaffold composed from sp2 carbon, oxygen and nitrogen atoms. Using Matlab, functions for molecule construction, crossover, mutation and fitness measurement were individually programmed. Fitness function was derived from AutoDock3.05 function which calculates molecular interaction energy with protein using grid map. The approach was successfully applied to design glutathione-S-transferase inhibitory molecule at sub-site of the binding pocket that is originally occupied by g-glutamyl and cysteinyl moieties of glutathione substrate. Starting from scratches, the approach was able to design molecular scaffolds complementarily filling the pocket.</p> 2023-06-30T00:00:00+00:00 Copyright (c) 2023 mohammed alqattan, Mohd Nizam Mordi https://phahs.knu.edu.iq/index.php/phahs/article/view/19 Assessment Of COVID-19 Virus Infection Among Patients With Atherosclerosis 2023-03-29T06:56:51+00:00 Salah Yousif [email protected] Ahmed Abdulsalam [email protected] Sevan Hassan [email protected] Shwan Amen [email protected] <p>Coronavirus disease 2019 (COVID-19) is a global pandemic affecting 185 countries and 3000000 patient’s worldwide COVID-19 is caused by severe acute respiratory syndrome coronavirus which invades cells through the angiotensin-converting enzyme receptors among patients with COVID-19 there is a high prevalence of cardiovascular disease.</p> <p>&nbsp;</p> <p><strong>Patients and Methods :</strong>The data were collected from patients which had been recovered from covid -19 virus and they have to progress in the disease to have atherosclerosis and some of the patients had a sign and symptoms of COPD. A total of 125 patients were taken for this study were taken for this study including both sex male and female with different age groups all of them admitted to specialized surgical-cardiac center hospital in Erbil City in Iraq. All of them suspected to have atherosclerosis so they will be detected by angiograph in catheterization laboratory in the hospital.</p> <p><strong>Conclusion:</strong> this study demonstrated that COVID-19 virus are also significant risk factors for coronary artery disease and patients who recovered from COVID-19 have had been suffered more from that increasing the severity of disease on them.</p> 2023-06-30T00:00:00+00:00 Copyright (c) 2023 Salah Hassan Yousif, Ahmed Abdulqader Abdulsalam , Sevan Hassan Bakir, Shwan Othman Amen