Citrullus colocynthis and Silbum Marian as therapeutic agent in metabolic syndrome Rrattus model

Authors

  • Abdullah Talal Al-Nuaymia College of pharmacy,University of Mosul, Iraq, College of Medicine, Ninevah Univrsity, Iraq
  • Muhammad Ahmed Ahmed Al Kataan College of Medicine, Ninevah Univrsity, Iraq https://orcid.org/0000-0002-9670-7494

DOI:

https://doi.org/10.59480/phahs.v1i2.16

Keywords:

phenolic compounds, glycemic profile, mitochondrial copies number, action potential, lactate: pyruvate ratio.

Abstract

Background: Plants represent a treasure chest with many unrevealed medical applications as hypoglycemic and antioxidant roles. A pathological condition characterized by hyperglycemia, insulin resistance, and dyslipidemia  known as metabolic syndrome.

Objectives: This work focuses on examining the hypoglycemic effect of three plants on a metabolic syndrome( MS)-induced animal model and studying the role of the extracted phenolic compounds on different mitochondrial function genomic parameters.

Methods: Citrullus colocynthis, Silbum Marian, and Rheum rhabarbarum phenolic compounds extracted and quantified using the Folin–Ciocalteu reagent, as described by Sánchez-Rangel et al. (2013).Forty albino rats were included in the work. They were divided into eight groups of five animals each as follows: negative control (normal), positive control (MS induced with fructose with no treatment), and MS treatment with Citrullus colocynthis, MS treatment with Silbum Marian, and MS treatment with Rheum rhabarbarum. Non-MS animals treated with Citrullus colocynthis Non-metabolic syndrome animals treated with Silbum Marian and non-MS animals treated with Rheum rhabarbarum. Serum glucose, Lipid profile, liver function tests, serum glucose, lactate, pyruvate, and molar lactate/pyruvate ratio. Genomic study was conducted by qPCR 

Conclusion: metabolic syndrome significantly reduce mitochondrial genome copies number. The application of the ethanolic extract of Citrullus colocynthis and Silbum Marian 

 

 

 

Author Biography

Abdullah Talal Al-Nuaymia, College of pharmacy,University of Mosul, Iraq, College of Medicine, Ninevah Univrsity, Iraq

 

 

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Published

2023-06-30

How to Cite

Al-Nuaymia, A. T., & Alkataan, M. (2023). Citrullus colocynthis and Silbum Marian as therapeutic agent in metabolic syndrome Rrattus model. Pharmacy and Applied Health Sciences, 2(1), 23–28. https://doi.org/10.59480/phahs.v1i2.16

Issue

Vol. 2 No. 1 (2023): Issue Three

Section

Research Article

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Copyright (c) 2023 Abdullah Talal Al-Nuaymia, Muhammad Ahmed Ahmed Al Kataan

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